Sets of Local Entropy-Enthalpy Change Leads to Global Entropy-Enthalpy Change in SERCA

A fundamental view of enthalpy–entropy compensation

Entropy-enthalpy compensation: fact or artifact?

The phenomenon of entropy-enthalpy (S-H) compensation is widely invoked as an explanatory principle in thermodynamic analyses of proteins, ligands, and nucleic acids. It has been suggested that this compensation is an intrinsic property of either complex, fluctuating, or aqueous systems. The questions examined here are whether the observed compensation is extra-thermodynamic (i.e., reflects any...

Balance of enthalpy and entropy in depletion forces

Solutes added to solutions often dramatically impact molecular processes ranging from the suspension or precipitation of colloids to biomolecular associations and protein folding. Here we revisit the origins of the effective attractive interactions that emerge between and within macromolecules immersed in solutions containing cosolutes that are preferentially excluded from the macromolecular in...

The Enthalpy Change on Adenosine Triphosphate

The energetics of ATP’ hydrolysis to ADP and P have been studied previously by combining either thermal (1, 2) or free energy (3-6) data for a number of chemical reactions according to the usual procedures of chemical thermodynamics. Such calculations, however, suffer from the fact that the uncertainties in each measurement are compounded in the final result. The ATPase properties of myosin off...

Enthalpy-entropy compensation at play in human copper ion transfer

Copper (Cu) is an essential trace element but toxic in free form. After cell uptake, Cu is transferred, via direct protein-protein interactions, from the chaperone Atox1 to the Wilson disease protein (WD) for incorporation into Cu-dependent enzymes. Cu binds to a conserved C(1)XXC(2) motif in the chaperone as well as in each of the cytoplasmic metal-binding domains of WD. Here, we dissect mecha...